Beth and I go to Knoxville from Atlanta once a month on business, a 215 mile trip one way turned around the next day. She also did Atlanta to Jacksonville, about 5+ hours, with a next day return. Neither one bothers her at all.
She keeps talking about going to Dallas, TX (800 miles each way) to see her mother... one day out, one day there, and one day back, but there's no way my ass would survive that trip. With her athletic background she's used to dealing with pain and hardship though, whereas when I hurt I figure it's time for a nice hotel.