I am 6'04" 230 and own a 12s. Both the 12s and 12Ss are too small for me. The only two Buells I feel like I fit on are the Ulysses and the Super TT. I will be buying a new bike this summer for that very reason, I don't fit well on the one I have right now. In my opinion there is not a huge difference between the 12s and 12Ss. In saying that I ride my 12s everywhere. But I feel cramped and need something bigger. Especially when it comes to the longer rides. I love the bike, just need something with a bigger frame.
Before you buy go ride them all. I have never seen a Buell dealership that does not do demo rides. I can't stress it enough ride them all before you buy. Don't just sit on them.