I have one in my collection, in .50 cal. No, it's not practical(for personal defens but some people hunt large game with them) but I have a few guns that are, so that one is just for fun, and to say i have it.
It does have more ass than the .44... The .50 AE has almost as much knock down power at 100 yards as the .44 Mag has at the muzzle.